Welcome to the Research Division at Georgia Reproductive Specialists. Our center leads the region in clinical reproductive research and is committed to continued advancement in the field. This section of our site contains links to current published research undertaken by the GRS scientific team, led by Michael J. Tucker, Ph.D.
Georgia Reproductive Specialists is the only independent reproductive endocrine practice in the world that supports its own citation-tracked, peer-review scientific/medical journal. The Journal of Experimental & Clinical Assisted Reproduction is accessioned by the U.S. National Library of Medicine and reports on important developments impacting the field of human reproductive medicine and surgery.
Please click on the links below for more information about our team's research activities.
1: Sills ES, Takeuchi T, Tanaka N, Neri QV, Palermo GD
Identification and isolation of embryonic stem cells in reproductive endocrinology: theoretical protocols for conservation of human embryos derived from in vitro fertilization.
Theor Biol Med Model. 2005 Jul 18;2(1):25
2: Sills ES
Conjoined twins, delivery and the memory of medicine.
J R Soc Med. 2005 Mar;98(3):135-6. No abstract available. PMID: 15738563 [PubMed - in process]
3: Sills ES, Vincent TT, Palermo GD
Article processing charges, funding, and open access publishing at Journal of Experimental & Clinical Assisted Reproduction.
J Exp Clin Assist Reprod. 2005 Jan 13;2(1):1. PMID: 15649322 [PubMed - as supplied by publisher]
4: Ghulmiyyah LM, Wehbe SA, Schwartz SA, Sills ES
Successful obstetrical management of 110-day intertwin delivery interval without cerclage: counseling and conservative management approach to extreme asynchronous twin birth.
BMC Pregnancy Childbirth. 2004 Dec 6;4(1):23. PMID: 15581427 [PubMed - as supplied by publisher]
5: Sills ES, Winston RM, Palermo GD
Journal of Experimental & Clinical Assisted Reproduction: shaping the future of research and practice in reproductive endocrinology/infertility.
J Exp Clin Assist Reprod. 2004 Sep 2;1(1):1. PMID: 15507153 [PubMed - as supplied by publisher]
6: Sills ES, Conway SC, Kaplan CR, Perloe M, Tucker MJ.
First successful case of in vitro fertilization-embryo transfer with venom immunotherapy for hymenoptera sting allergy.
Clin Mol Allergy. 2004 Oct 19;2(1):11. PMID: 15494069 [PubMed - as supplied by publisher]
7: Sills ES, Ghulmiyyah LM, Wehbe SA, Atkinson PF, Perloe M, Tucker MJ.
Microstructural observations of villous and membrane histology in monochorionic triplet placenta after in vitro fertilization.
Histol Histopathol. 2004 Oct;19(4):1241-4. Review. PMID: 15375768 [PubMed - indexed for MEDLINE]
8: Sills ES, Perloe M, Stamm LJ, Kaplan CR, Tucker MJ
Medical and psychological management of recurrent abortion, history of postneonatal death, ectopic pregnancy and infertility: successful implementation of IVF for multifactorial reproductive dysfunction. A case report.
Clin Exp Obstet Gynecol. 2004;31(2):143-6.
9: Liebermann J, Tucker MJ
Vitrifying and warming of human oocytes, embryos, and blastocysts: vitrification procedures as an alternative to conventional cryopreservation.
Methods Mol Biol. 2004;254:345-64.
10: Sills ES, Takeuchi T, Tucker MJ, Palermo GD
Genetic and epigenetic modifications associated with human ooplasm donation and mitochondrial heteroplasmy - considerations for interpreting studies of heritability and reproductive outcome.
Med Hypotheses. 2004;62(4):612-7.
11: Tucker MJ, Shipley S, Liebermann J
Conventional technologies for cryopreservation of human oocytes and embryos.
Methods Mol Biol. 2004;254:325-44.
12: Sills ES, Fryman JT, Perloe M, Michels KB, Tucker MJ
Chromatin fluorescence characterisitics and standard semen analysis parameters: correlations observed in andrology testing among 136 males referred for infertility evaluation.
J Obstet Gynaecol 2004 Jan; 24(1): 74-77
14: Sills ES, Kaplan CR, Perloe M, Tucker MJ
Laparoscopic approach to an uncommon adnexal neoplasm associated with infertility: serous cystadenofibroma of the fallopian tube.
J Am Assoc Gynecol Laparosc. 2003 Nov;10(4):545-7.
16: Ghulmiyyah LM, Perloe M, Tucker MJ, Zimmermann JH, Eller DP, Sills ES
Monochorionic-triamniotic triplet pregnancy after intracytoplasmic sperm injection, assisted embryo hatching, and two-embryo transfer: first reported case following IVF.
BMC Pregnancy Childbirth. Epub 2003 Aug 08
17: Han TS, Sagoskin AW, Graham JR, Tucker MJ, Liebermann J
Laser-assisted human embryo biopsy on the third day of development for preimplantation genetic diagnosis: two successful case reports.
Fertil Steril. 2003 Aug; 80(2): 453-455
18: Sills ES, Drews CD, Perloe M, Tucker MJ, Kaplan CR, Palermo GD
Absence of profound hyperinsulinism in polycystic ovary syndrome is associated with subtle elevations in the plasminogen activator inhibitor system.
Gynecol Endocrinol. 2003 Jun; 17(3): 231-7.
19: Sills ES, Perloe M, Kaplan CR, Schlegel PN, Palermo GD
Bilateral orchiectomy for the surgical treatment of complete androgen insensitivity syndrome: patient outcome after 1 year of follow-up.
J Laparoendosc Adv Surg Tech A. 2003 Jun 13 (3): 193-7
20: Liebermann J, Tucker MJ, Sills ES
Cryoloop vitrification in assisted reproduction: analysis of survival rates in > 1000 human oocytes after ultra-rapid cooling with polymer augmented cryoprotectants
Clin Exp Obstet Gynecol. 2003; 30 (2-3): 125-9
22: Sills ES, Tucker MJ.
First experience with intracytoplasmic sperm injection for extreme oligozoospermia associated with Crohn's disease and 6-mercaptopurine chemotherapy.
Asian J Androl. 2003 Mar;5(1):76-8.
28: Sills ES, Palermo GD.
Correspondence on article on major birth defects after assisted reproduction
N Engl J Med, Vol. 347, No. 18 - October 31, 2002
29: Sills ES, Palermo GD.
Preimplantation Genetic Diagnosis for Elective Sex Selection, the IVF Market Economy, and the Child - Another Long Day's Journey Into Night?
J Assist Reprod Genet 2002 Sep;19(9):433-7
30: Liebermann J, Tucker MJ
Effect of carrier system on the yield of human oocytes and embryos as assessed by survival and developmental potential after vitrification
Reproduction 2002 Oct;124(4):483-9
31: Sills ES, Palermo GD
Intrauterine pregnancy following low-dose gonadotropin ovulation induction and direct intraperitoneal insemination for severe cervical stenosis
BMC Pregnancy and Childbirth 2002 2:9
32: Sills ES, Harmon KE, Tucker MJ.
First reported convergence of premature ovarian failure and cutis marmorata telangiectatica congenita.
Fertil Steril 2002 Dec;78(6):1314-6
33: Porter RN, Tucker MJ, Graham J, Sills ES.
Advanced embryo development during extended in vitro culture: observations of formation and hatching patterns in non-transferred human blastocysts.
Hum Fertil (Camb) 2002 Nov;5(4):215-20
34: Sills ES, Perloe M, Kaplan CR, Sweitzer CL, Morton PC, Tucker MJ.
Uncomplicated pregnancy and normal singleton delivery after surgical excision of heterotopic (cornual) pregnancy following in vitro fertilization/embryo transfer.
Arch Gynecol Obstet. 2002 Jul;266(3):181-4.
36: Saini J, Kuczynski E, Gretz HF 3rd, Sills ES.
Supracervical hysterectomy versus total abdominal hysterectomy: perceived effects on sexual function.
BMC Womens Health. 2002;2(1):1.
37: Sills ES.
11 September and after.
J R Soc Med. 2002 Feb;95(2):111-2. No abstract available.
38: Sills ES, Sholes TE, Perloe M, Kaplan CR, Davis JG, Tucker MJ.
Characterization of a novel receptor mutation A-->T at exon 4 in complete androgen insensitivity syndrome and a carrier sibling via bidirectional polymorphism sequence analysis.
Int J Mol Med. 2002 Jan;9(1):45-8.
39: Sills ES, Vrbikova J, Kastratovic-Kotlica B.
Conjoined twins, conception, pregnancy, and delivery: a reproductive history of the pygopagus Blazek sisters (1878-1922).
Am J Obstet Gynecol. 2001 Dec;185(6):1396-402.
40: Sills ES, Perloe M, Tucker MJ, Kaplan CR, Palermo GD.
Successful ovulation induction, conception, and normal delivery after chronic therapy with etanercept: a recombinant fusion anti-cytokine treatment for rheumatoid arthritis.
Am J Reprod Immunol. 2001 Nov;46(5):366-8.
41: Sills ES, Takeuchi T, Rosenwaks Z, Palermo GD.
Reprogramming somatic cell differentiation and the Hayflick Limit: contrasting two modern molecular bioengineering aims and their impact on the future of mankind.
J Assist Reprod Genet. 2001 Aug;18(8):468-70.
43: Sills ES, Perloe M, Tucker MJ, Kaplan CR, Genton MG, Schattman GL.
Diagnostic and treatment characteristics of polycystic ovary syndrome: descriptive measurements of patient perception and awareness from 657 confidential self-reports.
BMC Womens Health. 2001;1(1):3.
44: Sills ES, Drews CD, Perloe M, Kaplan CR, Tucker MJ.
Periovulatory serum human chorionic gonadotropin (hCG) concentrations following subcutaneous and intramuscular nonrecombinant hCG use during ovulation induction: a prospective, randomized trial.
Fertil Steril. 2001 Aug;76(2):397-9.
45: Tucker MJ
Morphological Scoring of Human Embryos and Its Relevance to Blastocyst Transfer
46: Sills ES, Tucker MJ, Palermo GD.
Assisted reproductive technologies and monozygous twins: implications for future study and clinical practice.
Twin Res. 2000 Dec;3(4):217-23. Review.
49: Sills ES, Poynor EA, Moomjy M.
Ovarian hyperstimulation and oophorectomy following accidental daily clomiphene citrate use over three consecutive months.
Reprod Toxicol. 2000 Nov-Dec;14(6):541-3.
50: Perloe M, Levy DP, Sills ES.
Strategies for ascertaining ovarian reserve among women suspected of subfertility.
Int J Fertil Womens Med. 2000 May-Jun;45(3):215-24. Review.
51: Sills ES, Perloe M, Palermo GD.
Correction of hyperinsulinemia in oligoovulatory women with clomiphene-resistant polycystic ovary syndrome: a review of therapeutic rationale and reproductive outcomes.
Eur J Obstet Gynecol Reprod Biol. 2000 Aug;91(2):135-41. Review.
54: Tucker M
Relevance of assisted hatching with blastocyst stage transfer.
Proceedings First World Congress on Controversies in Obstetrics, Gynecology & Infertility, Prague, Czech Republic, Oct 28-31, 1999; Monduzzi, Bologna, Italy, pp49-52.
56: Sills ES, Goldschlag D, Levy DP, Davis OK, Rosenwaks Z.
Preimplantation genetic diagnosis: considerations for use in elective human embryo sex selection.
J Assist Reprod Genet. 1999 Nov;16(10):509-11. No abstract available.
57: Perloe M, Sills ES
Metformin treatment of clomiphene resistant polycystic ovary syndrome.
Allahbadia G (ed): in Manual of Ovulation Induction October 99, Rotunda Press London-Bombay
58: Sills ES, Levy DP, Moomjy M, McGee M, Rosenwaks Z.
A prospective, randomized comparison of ovulation induction using highly purified follicle-stimulating hormone alone and with recombinant human luteinizing hormone in in-vitro fertilization.
Hum Reprod. 1999 Sep;14(9):2230-5.
69: Sills ES, Schattman GL, Veeck LL, Liu HC, Prasad M, Rosenwaks Z.
Characteristics of consecutive in vitro fertilization cycles among patients treated with follicle-stimulating hormone (FSH) and human menopausal gonadotropin versus FSH alone.
Fertil Steril. 1998 May;69(5):831-5.
79: Tucker MJ, Morton PC, Wright G, Sweitzer CL, Ingargiola PE, Chan SYW
Paternal influence on embryogenesis and pregnancy in assisted human reproduction.
JBFS 1(2), Hum Reprod 1996 11, Natl Suppl 90-95
80: Tucker MJ, Wright G, Morton PC, Li S, Massey JB, Kort HI
Preliminary experience with human oocyte cryopreservation using 1,2-propanediol and sucrose.
Hum Reprod 1996 11:1513-1515
87: Tucker MJ, Elsner CW, Morton PC, Witt MA, Wright G
Pregnancies following intracytoplasmic injection of testicular and epididymal sperm for treatment of obstructive azoospermia.
Hum Reprod 1995:486-489
90: Tucker MJ, Wiker SR, Wright G, Morton PC, Toledo AA
Treatment of male infertility and idiopathic failure to fertilize in vitro with under zona insemination and direct egg injection.
Am J Obstet Gynecol 1993 169:324-332.
91: Sills ES, Mabie WC.
A refractory case of herpes gestationis.
J Tenn Med Assoc. 1992 Dec;85(12):559-60. No abstract available.
92: Sills ES, Mabie BC.
Herpes gestationis following normal first pregnancy.
J Tenn Med Assoc. 1991 Sep;84(9):445. No abstract available.
PMID: 1921388 [PubMed - indexed for MEDLINE]
93: Hill DL, Kuyt F, Vogel M, Kaplan C
Delivered twins from electroejaculation and tubal embryo transfer.
J In Vitro Fert Embryo Transfer 8:196-298, 1991
95: Kaplan CR, Groff TR and Olive DL
Ovarian hyperstimulation syndrome following a leuprolide-human menopausal gonadotropin GIFT cycle.
Infertility 12:127-132, 1990
96: Kaplan CR and Schenken RS
Endocrine Physiology
The Female Breast and Its Disorders: Essentials of Diagnosis and Management.
Mitchell GA and Bassett L (Ed.), Williams and Wilkins, Baltimore, 1990, 22-44.
